Importance of inflammation in arteriosclerotic plaque destabilization and rupture
نویسندگان
چکیده
منابع مشابه
Proteolysis of pericellular matrix: a process linking inflammation to plaque destabilization and rupture.
The two major general cellular concepts in atherogenesis, foam cell formation and growth of smooth muscle cells (SMCs) in the arterial intima, have not been able to satisfactorily explain the evolution of advanced complex atherosclerotic lesions behind acute atherothrombotic events leading to acute coronary syndromes. Rather, in terms of intimal pathophysiology, the two above cellular processes...
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BACKGROUND AND PURPOSE The simplistic view of atherosclerosis as a disorder of pathological lipid deposition has been redefined by the more complex concept of an ongoing inflammatory response. SUMMARY OF REVIEW Apolipoprotein E and low-density lipoprotein (LDL)-receptor-deficient mice develop accelerated atherosclerosis allowing in-depth pathophysiological investigations. Atherosclerotic plaq...
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OBJECTIVE Although plaque erosion causes approximately 40% of all coronary thrombi and disproportionally affects women more than men, its mechanism is not well understood. The role of tissue mechanics in plaque rupture and regulation of mechanosensitive inflammatory proteins is well established, but their role in plaque erosion is unknown. Given obvious differences in morphology between plaque ...
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OBJECTIVE Inflammatory monocytes/macrophages produce various proteinases, including matrix metalloproteinases, and degradation of the extracellular matrix by these activated proteinases weakens the mechanical strength of atherosclerotic plaques, which results in a rupture of the plaque. Peroxisome proliferator-activated receptor-γ induces a polarity shift of monocytes/macrophages toward less in...
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It remains challenging to predict the risk of rupture for a specific atherosclerotic plaque timely, a thrombotic trigger tightly linked to inflammation. CD11b, is a biomarker abundant on inflammatory cells, not restricted to monocytes/macrophages. In this study, we fabricated a probe named as (99m)Tc-MAG3-anti-CD11b for detecting inflamed atherosclerotic plaques with single photon emission comp...
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ژورنال
عنوان ژورنال: Military Medical and Pharmaceutical Journal of Serbia
سال: 2005
ISSN: 0042-8450,2406-0720
DOI: 10.2298/vsp0509649t